Job opportunities

Postdoctoral position in redox signaling kinetics

Position: A postdoctoral Research position is immediately available for structure-function studies of proteins that control signaling during oxidative stress. Successful candidates will join an exciting research environment of the Messens VIB-laboratory in the Structural Biology Research Center in Brussels. The Messens laboratory is recognized as a world leader in the redox field, and the lab provides an outstanding position in protein biochemistry and structural biology, in a highly dynamic and team-oriented research group. You will work on the Strategic Research Project ‘The far reaches of enzymology in health and disease - Kinetics along signal transduction pathways within complex systems’. In this cutting-edge research environment, you will tackle essential biological problems in protein signaling.

Project: In the projects of the lab, we are analyzing the dynamics of the sulfur-proteome under varying oxidative stress conditions by identifying the proteins that are post translational modified by reactive oxygen species (ROS) on their cysteines forming a sulfenic acid (Cys-SOH) and on their methionines forming a sulfoxide (Met-SO). These reversible post-transcriptional modifications function as “thiol-switches” which alter the biochemical properties of redox sensing proteins. We aim to establish a detailed kinetic and structural view of the mode of action of these redox proteins, in order to scrutinize their role in signaling during oxidative stress signaling.

Requirements: Applicants should have a chemical background, obtained a PhD in the last 5 years within the field of protein biochemistry and should have hands-on expertise with kinetic techniques. Fluent knowledge of English is a must. Experience with biophysical techniques and structural biology is a plus, but not required.

Please send a cover letter discussing your interests in the laboratory and the project as well as your CV and a list of 3 individuals as references to