Jean-François is Welbio Investigator, Senior Research Associate of the FRS-FNRS and Professor at the Université catholique de Louvain (UCL). During his doctoral work at the de Duve Institute in the lab of Emile Van Schaftingen, he discovered a large family of phosphotransferases that form a phosphoenzyme on an aspartate residue. Then he moved to the lab of James Bardwell at the University of Michigan to work on the proteins that catalyze the formation of protein disulfide bonds in the bacterial periplasm. In 2004, he established his lab at the de Duve Institute of the UCL in Brussels. He is author or co-author of more than 70 peer-reviewed publications, most of which focus on disulfide bond formation and protein folding in the periplasm and the detection of envelope stress.