Brussels Center for Redox Biology

Job opportunities

VUB | VIB | de Duve Institute

Copyright 2017

Postdoctoral position enzyme kinetics

Position: A postdoctoral Research position is immediately available for kinetic studies of enzymes involved in redox metabolite signaling. Successful candidates will join an exciting research environment of the Messens VIB-laboratory at the Center for Structural Biology in Brussels. The Messens laboratory is recognized as a world leader in the redox field, and the lab provides an outstanding position in enzyme kinetics, in a highly dynamic and team-oriented research group. In this cutting-edge research environment, you will tackle essential biological problems using your enzyme kinetic expertise.

Mission of the lab: We decipher how cells sense redox metabolites and transduce stimuli into downstream biological effects. Knowledge of the mechanisms by which sensors and transducers function are invaluable in understanding how redox homeostasis pathways can be engineered with the ultimate goal to improve oxidative stress resistance in plants and to identify therapeutic targets in redox diseases.

Your daily lab duties:

·Perform enzyme kinetic analyses including steady-state kinetic and rapid reaction kinetics

·Perform protein expression and purification for biochemical assays and crystallization

·Develop appropriate methods for the determination of the mechanism of action of enzymes

·Collaborate with scientists in our research group

·Provide expertise in design, optimization, verification, and documentation of enzyme assays

·Serve as mentor to undergraduate and graduate students in the laboratory

·Author/co-author articles for publication and presentation in scientific journals

Requirements: Applicants should have obtained a PhD in the last 5 years within the field of protein biochemistry, and should have a strong theoretical enzyme kinetic and biophysical background. Fluency in English is a must. Experience with structural biology and redox biochemistry is a plus, but not required.

Please send a cover letter discussing your interests in the laboratory and the project as well as your CV and a list of 3 individuals as references to joris.messens@vib-vub.be.

Postdoctoral position molecular biology and cancer research

A position is immediately available for a highly motivated postdoctoral researcher with a background in molecular biology and cancer research; prior experience in the field of redox biology would be beneficial, but is not necessary. The successful candidate would work in a highly interdisciplinary field encompassing cancer cell biology and redox metabolite signaling pathways.

Specifically, you will be working on the translational aspects that integrate redox biochemistry and cancer biology. The main aim of the project is the development of novel redox-related therapeutic approaches against cancer. The project is a joint effort between the Vrije Universiteit Brussels (VUB), Belgium and the University of Göttingen, Germany and will be coordinated by Prof. Joris Messens (Brussels), Prof. Ivan Bogeski (Göttingen) and Prof. Vsevolod Belousov (Göttingen).

The position is available for three years. The successful candidate is expected to spend the first year at the University of Göttingen, and the remaining in Brussels. Nevertheless, short-term research stays in Göttingen or Brussels during the whole period are likely.

Your profile:

·Academic degree (Ph.D.) in biology, medicine, biochemistry, or related field

·Hands-on expertise with human cell cultures, and genome editing techniques

·Ability to independently take responsibility over your project

·Strong teamwork and communication skills

·Reliability, attention to detail and effective time management

·Flexibility and willingness to travel and work in two laboratories

·Excellent command of both written and oral English is essential

Please submit your application in a single PDF file with CV, a letter stating research and career interests, and expected availability date to: Joris.Messens@vub.be and ivan.bogeski@med.uni-goettingen.de